Other Attachments: The application must include the following attachment. Eligibility: The overarching goal of this pilot program is to enhance the retention of investigators facing critical life events who are transitioning to the first renewal of their first independent research project grant award or to a second new NIH research project grant award. The MIRA will replace all current NIGMS research funding of the laboratory of the PD/ PI with the exception of those listed in Section I under Overlap during peer review. Upon receipt, applications will be evaluated for completeness and compliance with application instructions by the Center for Scientific Review and the National Institute of General Medical Sciences. This NOFO does not allow resubmissions, although a new application can be submitted after an unsuccessful attempt as long as the PD/PI remains eligible, as defined above. 2. To support research projects that will enhance the capability of resources to serve biomedical research. Larger award amount than the current average NIGMS R01 award to ESIs. A temporary change may be allowed with NIGMS' prior approval under circumstances such as sabbatical leave, medical conditions, disability, or personal or family situations. Get the latest scientific news and resources on diseases of the bones, joints, muscles, and skin from the NIAMS. Investigators with K awards from another NIH institute may receive an NIGMS MIRA but will be required to adjust their person-months effort on those awards to be smaller than the person-months effort committed to MIRA. Once the multiple PI application is funded, you lose your ESIstatus. To be eligible, PDs/PIs must hold only one active NIH Research Project Grant. Read more about NIAMS Small Business Grants. Candidates must have completed their specialty and, if applicable, subspecialty training prior to receiving an award.Duration: 3 to 5 yearsProvisions: Support is provided for salary up to $100,000 for a minimum 75% effort (with the exception of orthopaedic surgeons, who may devote a minimum of 50% effort*), fringe benefits, and other research expenses up to $30,000.Applications Due: Standard dates*Please see NOT-AR-16-012, Midcareer Investigator Award in Patient-Oriented Research, To support protected time for clinicians to allow them time for patient-oriented research and to act as mentors for beginning clinical investigators. Does the project incorporate efficiencies and utilize existing resources (e.g., CTSAs, practice-based research networks, electronic medical records, administrative database, or patient registries) to increase the efficiency of participant enrollment and data collection, as appropriate? All instructions in the SF424 (R&R) Application Guide, PA-20-272, and NOT-OD-23-032 must be followed. Note that ESI status can be extended beyond the normal 10-year window after completion of the terminal research degree or medical residency for certain life or career events, as described inNOT-OD-19-125and on theNIH website. Does the design/research plan include innovative elements, as appropriate, that enhance its sensitivity, potential for information or potential to advance scientific knowledge or clinical practice? The MIRA PD/PI will be required to relinquish their involvement in the multi-component grant at the end of its competitive segment. Only single PD/PI applications are allowed. Do they have appropriate experience and training? Because most institutions expect some commitment from investigators to administrative, teaching, and/or clinical duties, any salary support for the PD/PI charged to the grant should generally be less than 51% of the PD/PI's annual salary and should in no case be more than the actual research effort the PD/PI will devote to the grant. and other dual doctoral degree students to extend their potential for a career in research in arthritis, muscle, bone, musculoskeletal, and/or skin diseases. Administrative Supplements to Existing NIH Grants and Cooperative Agreements NIHTurning Discovery Into Health The following types of Higher Education Institutions are always encouraged to apply for NIH support as Public or Private Institutions of Higher Education: Nonprofits Other Than Institutions of Higher Education. Box 94095 | Baton Rouge, LA 70804-9095 PHYSICAL ADDRESS: 602 North 5th Street, Suite 621 | Baton Rouge, LA Following the Financial Management Plan, NIAID funds most applications in order by percentile (R01 only) or overall impact score (others). For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: Generaland Part II: Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Recipients, and Activities, including of note, but not limited to: If a recipient is successful and receives a Notice of Award, in accepting the award, the recipient agrees that any activities under the award are subject to all provisions currently in effect or implemented during the period of the award, other Department regulations and policies in effect at the time of the award, and applicable statutory provisions. If the proposed research involves human subjects and/or NIH-defined clinical research, are the plans to address: (1) the protection of human subjects from research risks, and (2) inclusion (or exclusion) of individuals on the basis of sex/gender, race, and ethnicity, as well as the inclusion or exclusion of individuals of all ages (including children and older adults), justified? After the award, research involving the addition of human subjects, vertebrate animals, stem cells, select agents, or a new foreign component would require prior approval by NIGMS staff according to existing policies and procedures. For additional information on review of the Vertebrate Animals section, please refer to the Worksheet for Review of the Vertebrate Animals Section. Only those application types listed here are allowed for this NOFO. The NIGMS Maximizing Investigators' Research Award (MIRA) provides support for the NIGMS-relevant program of research in an investigator's laboratory. Institutional Commitment to Candidate's Research Career Development attachment (1-page limit): Note: For help accessing PDF, RTF, MS Word, Excel, PowerPoint, Audio or Video files, see Help Downloading Files. Is a refinement, improvement, or new application of theoretical concepts, approaches or methodologies, instrumentation, or interventions proposed? Open Mike: Introducing the In FY 2009, NIH announced a new policy involving the identification of early stage investigators (ESIs). Contact Center Telephone: 800-518-4726 Only the review criteria described below will be considered in the review process. Provide a rationale for the changes in the context of the originally proposed research program and explain how the research continues to fit within NIGMS mission interests. Because the MIRA is intended to support a significant and ambitious program of research, the PD/PI is required to devote at least 51% of their total research effort to this award. 21. Applications may request up to $250,000 direct costs per year. For Established Investigator or New Investigator MIRA applications, it is NOT okay to have similar ReWARD application under review at the same time. If equipment is requested in Section C, do not add the equipment budget in Section F. If subaward/consortium costs are requested, the subaward/consortium direct costs (not including consortium F&A) should be included in the "Requested Direct Costs. If there are further questions, applicants should consult with the NIGMS Scientific/Research staff (listed in Section VII. This NOFO requires a Plan for Enhancing Diverse Perspectives (PEDP) as part of the application (see Section IV.2 SF424(R&R) Other Project Information. Where necessary, PD/PIs and participants may be appropriately contacted after the completion of the grant period for updates on participants subsequent outcomes. The letter should also detail the institutional commitment to the applicant's return to full productivity and research career trajectory at the end of the supplement period. Section III. Other NIH institutes set special paylines for ESIs as well. Investigators proposing NIH-defined clinical trials may refer to the Research Methods Resources website for information about developing statistical methods and study designs. Please visit the NIH Loan Repayment Program to learn about eligibility information, application instructions and more.Contact: Neil Roberts Applicants who receive funding as the PD/PI of an R01, RM1, SC1, DP1, DP2, or any other type of disqualifying award, including certain ones listed above, prior to issuance of the ESI MIRA become ineligible to receive the award. Larger award amount than the current average NIGMS R01 award to ESIs. All PD(s)/PI(s) must include their eRA Commons ID in the Credential field of the Senior/Key Person Profile form. At least 40% of the research project is to be conducted by the small business concern, and at least 30% of the work is to be conducted by the single, partnering research institution. The supplement is not retroactive. FAPIIS requires Federal award making officials to review and consider information about an applicant in the designated integrity and performance system (currently FAPIIS) prior to making an award. Investigational New Drug or Investigational Device Exemption Requirements: Consistent with federal regulations, clinical research projects involving the use of investigational therapeutics, vaccines, or other medical interventions (including licensed products and devices for a purpose other than that for which they were licensed) in humans under a research protocol must be performed under a Food and Drug Administration (FDA) investigational new drug (IND) or investigational device exemption (IDE). WebThe goal of this initiative is to engage and support early career investigators interested in basic and clinical research focused on multiple myeloma and its precursor conditions, with the goal of advancing our understanding of myeloma disease biology, disease risk, and treatment response and relapse. Support will be provided for up to 2 years (R61 Phase) to perform critical experiments that rigorously test the proposed concept. A New Investigator (NI) is an NIH research grant applicant who has not yet competed successfully for a substantial, competing NIH research grant. NIAMS has 2 receipt dates for this program: May 1st and Nov 1st. Will the program benefit from unique features of the scientific environment, subject populations, or collaborative arrangements? Applications for the STAR program must be submitted in the second or third year of the current award. ", 6. For guidance on meeting the legal obligation to take reasonable steps to ensure meaningful access to programs or activities by limited English proficient individuals see, For information on an institutions specific legal obligations for serving qualified individuals with disabilities, including providing program access, reasonable modifications, and to provide effective communication, see, HHS funded health and education programs must be administered in an environment free of sexual harassment, see, For guidance on administering programs in compliance with applicable federal religious nondiscrimination laws and applicable federal conscience protection and associated anti-discrimination laws see. Other Information for award authorities and regulations. Services, National Institutes of Health: Reduce the time spent by researchers writing and reviewing grant applications, allowing them to spend more time conducting research. To strengthen the biomedical research and research training capability of ethnic minority institutions, and thus establish a more favorable milieu for increasing the involvement of minority faculty and students in biomedical research. The NIH Policy on Late Submission of Grant Applications states that failure to complete registrations in advance of a due date is not a valid reason for a late submission. U.S. citizenship or permanent resident status is required. Similarly, early career stage applicants may not have yet published independently as senior or corresponding authors, and the absence of these publications should not be viewed as a weakness. Preliminary dataare not required and justification for the proposed work may be provided through literature citations, data from other sources, or data generated by the applicant as a graduate student or postdoctoral fellow. The award can provide support for certain basic shared resources, including clinical components, which facilitate the total research effort. state the statute or rule or regulation found to have been violated and which resulted in the suspension or revocation: 2. state the penalty imposed for the violation; and. Applicants who receive funding as the PD/PI of an R01, RM1, SC1, DP1, DP2, or any other type of disqualifying award, including certain ones listed above, prior to issuance Is there a plan to obtain required study agent(s)? Substantial Federal programmatic staff involvement is intended to assist investigators during performance of the research activities, as defined in the terms and conditions of award. All registrations must be completed prior to the application being submitted. The application forms package specific to this opportunity must be accessed through ASSIST, Grants.gov Workspace or an institutional system-to-system solution. To what extent will features of the environment described in the Plan for Enhancing Diverse Perspectives (e.g., collaborative arrangements, geographic diversity, institutional support) contribute to the success of the project? Is there a plan to complete data analysis within the proposed period of the award? Does my renewed NHLBI R01 award qualify as an NHLBI-funded NIH Early Stage Investigator award and therefore meet that eligibility criterion for the Emerging Investigator Award (EIA)? If the goals of the MIRA have changed, complete section B.1.a. Pregnancy and childbirth appear to be a significant contributor to the underemployment of women scientists and engineers, given that pregnancy can impact research productivity. Given that the MIRA is meant to provide support for a research program within the NIGMS mission in a PDs/PIs laboratory, and may include multiple projects on disparate topics, there is no obligation for the PD/PI to present a single unifying theme. NIH Will Consider Your Career Stage If You submit an R01 grant application You are an Early Stage Investigator (ESI) A New Investigator is someone who has not Form Approved OMB# 0925-0648 Exp. Reviewers will assess the use of chimpanzees as they would any other application proposing the use of vertebrate animals. Each SCOR should develop an interdisciplinary research agenda bridging basic and clinical research on sex/gender factors underlying a priority womens health issue.Duration: 5 yearsBudget Cap: $750,000 direct costsApplications Due: By RFA onlyContact:NIAMSCenters Program, Minority Biomedical Research Support - MBRS. The following items are to be included in the PH 398 Research Plan Form: 2. is acting as the primary caregiver for an ailing spouse, child, partner or a member of the immediate family. Does the NIH Directors New Innovator Award remove your Early Stage Investigator status? Software within the eRA Commons will check first for New Investigator (NI) status based on the individuals previous award history. All instructions in the SF424 (R&R) Application Guide must be followed. Are the relevant concepts and methods sufficiently established by the prior literature, previous work or preliminary data? After the peer review of the application is completed, the PD/PI will be able to access his or her Summary Statement (written critique) via theeRA Commons. WebSuccess Rates of R01 Applications from Early Stage Investigators. Applications due: Standard datesAdditional Information: Active R03 funding opportunity: PAR-22-119 Following initial peer review, recommended applications will receive a second level of review by the National Advisory General Medical Sciences Council. An application does not need to be strong in all categories to be judged likely to have major scientific impact. I am thrilled to announce that I have been awarded a new @NIDDKgov /@NIH Stephen I. Katz Early-Stage Investigator Research Project Grant-R01 providing $2.3 Increase the stability of funding for NIGMS-supported investigators, which could enhance their ability to take on ambitious scientific projects and approach problems more creatively. All PD(s)/PI(s) must have an eRA Commons account. Is the scientific rationale/premise of the study based on previously well-designed preclinical and/or clinical research? Contact: Xibin WangApplications Due: Standard dates Additional Information: Office of Extramural Research: Small Business Innovation Research (SBIR) and Small Business Technology (STTR) Programs, Small Business Innovation Research (SBIR) Program. Non-domestic (non-U.S.) components of U.S. The total research effort should be determined in person-months and should not include time expended toward teaching, administration not directly related to the PD's/PI's research, and/or clinical duties. 3. Engagement from different types of institutions and organizations (e.g., research-intensive, undergraduate-focused, minority-serving, community-based). The following section supplements the instructions found in the SF424 (R&R) Application Guide and should be used for preparing an application to this NOFO. Department of Health and Human Services, Grants & Funding: The NIAMS Extramural Program, The Stephen I. Katz Early Stage Investigator Research Grant Program, Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed), Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Basic Experimental Studies with Humans Required), U.S. Department of Health and Human Services. Are the planned recruitment timelines feasible and is the plan to monitor accrual adequate? These are agreements between NIH and the award recipient in which the NIH acts as the partner in the research effort for projects similar to grants. If a Changed/Corrected application is submitted after the deadline, the application will be considered late. b) Under Section B.4, Opportunities for Training and Professional Development, indicate if individual development plans have been used for any graduate students and/or post-doctoral fellows supported by this award. Innovation and the potential for commercialization are two important aspects of the review criteria considered in the scientific and technical merit evaluation process. Helping investigators transition to independence is a high priority for NIH and an important funding consideration for NINDS. A description of how the supplement funds will be used to offset the impact to the research program as a result of the critical life event. A full list of policy notices published by NIH is provided in the NIH Guide for Grants and Contracts. As part of a bi-phasic approach to funding exploratory and/or developmental research, the UG3 provides support for the first phase of the award. Research Innovations for Scientific Knowledge (RISK), Focuses on innovative research within the NIAMS mission by encouraging applicants to pursue unusual observations, test imaginative hypotheses, investigate creative concepts, and build ground-breaking paradigms, all of which deviate significantly from the current prevailing theories or practice. So R01s from experienced investigators or experience PIs are discussed separately as a cluster or a group. Applications must be submitted electronically following the instructions described in the SF424 (R&R) Application Guide. For projects involving key biological and/or chemical resources, reviewers will comment on the brief plans proposed for identifying and ensuring the validity of those resources. You might also consider participating in the NIH Center for Scientific Review's. As required by section 3010 of Public Law 111-212, all information posted in the designated integrity and performance system on or after April 15, 2011, except past performance reviews required for Federal procurement contracts, will be publicly available. Plan for Enhancing Diverse Perspectives (PEDP) (1-page maximum): All applications must include a summary of strategies to advance the scientific and technical merit of the proposed project through expanded inclusivity. Are the institutional support, equipment and other physical resources available to the investigators adequate for the proposed program? Outreach and planned engagement activities to enhance recruitment of individuals from diverse groups as research participants including those from under-represented backgrounds. Although only UH2 awardees are generally eligible to apply for UH3 support, specific program initiatives may establish eligibility criteria under which applications could be accepted from applicants demonstrating progress equivalent to that expected under UH2. Any individual with the skills, knowledge, and resources necessary to carry out the proposed research as the PD/PI is invited to work with their organization to develop an application for support. For individuals identified as NIs, the software will calculate the ten-year window of Early Stage Investigator (ESI) status based on the date of the terminal research degree or the residency end date entered in the investigators Profile. Budget: Do not include the number of person months or direct costs. Activation of the independent award phase is administrative, and is contingent upon the investigator securing an independent research position. The outcomes of these critical experiments will be the central determining factor for the activation of the R33 Phase. I am thrilled to announce that I have been awarded a new @NIDDKgov /@NIH Stephen I. Katz Early-Stage Investigator Research Project Grant-R01 providing $2.3 million in funding over five years to advance our research efforts Information on the submission process and a definition of on-time submission are provided in the SF424 (R&R) Application Guide. An official website of the United States government, NINDS No Longer Participates in the Katz Program. The ORWH promotes, stimulates, and supports efforts to improve the health of women through biomedical and behavioral research. Biographical Sketches: A biosketch should only be provided for the PD/PI and, in rare cases, for collaborator(s) receiving financial support from the MIRA. Research Strategy (6-page limit) to include: 2. Scientific and technical merit of the proposed research program as determined by scientific peer review. *** For the BTOD grants, the PD/PI must maintain 51% research effort toward their MIRA, and 3 person months' effort toward the BTOD. For step-by-step instructions, see the ESI Extension Request online help or watch the video tutorial ESI Status Extension Request on the eRA Videos page. In Section C: Equipment Description, enter budget request for equipment. It is possible to get exceptions for interruptions in your career due to the birth of a child and other situations. To what extent do the efforts described in the Plan for Enhancing Diverse Perspectives further the significance of the project? The situation will be evaluated on a case-by-case basis and the MIRA could be terminated if continued support is not warranted. 504.236.4410. toni.ledet@la.gov. Generally, summary statements will be available no later than 30 days before Council. Before proceeding with any supplement request, PIs are advised to contact their program officer to discuss scientific need and their grants management specialist to discuss budget and policy issues. Recipients must comply with any funding restrictions described in Section IV.6. NIAMS strongly recommends applicants submit an X02 pre-application.Duration: up to 2 years for the R61 Phase and 1 year for the R33 PhaseBudget Cap: $250,000 direct costs per yearApplications Due: By RFA only, Applicant Information Webinar for NIAMS Research Innovations for Scientific Knowledge (RISK) (X02, R61/R33), FAQsNIAMS Research Innovations for Scientific Knowledge (RISK) (X02, R61/R33), Active Resource-based P30 funding opportunities, Provides critical research infrastructure, shared facilities, services, and resources to groups of investigators, with the broad overall goal of accelerating, enriching, and enhancing the effectiveness of ongoing basic, translational, and clinical research and promoting new research within the NIAMS mission. This initiative is not subject to intergovernmental review. Plan to utilize the project infrastructure (i.e., research and structure) to support career-enhancing research opportunities for diverse junior, early- and mid-career researchers. The STAR Program will support activities that effectively allow these investigators to expand and explore new opportunities within the broader scope of currently funded, peer-reviewed research project to facilitate the transition from a single, structured research project to a research program. Each project supported through this mechanism should contribute to or be directly related to the common theme of the total research effort. Each fiscal year (FY), NIAID sets initial paylines conservatively and sets final paylines later. NIH NOFOs outline intended research goals and objectives. Itemized budget information is not required and will not be accepted. An independent research award is considered to be a R01 or equivalent award. Institutional Review Board or Independent Ethics Committee Approval: Recipient institutions must ensure that all protocols are reviewed by their IRB or IEC. Does the PD/PI show promise as a mentor of undergraduate and graduate students, and postdoctoral associates, and the potential to establish a record of professional service?