The following are not technically blister packs and do not use preformed blisters made from sturdy PVC plastic. Blister packaging is a widely used packaging form. There are two types of knurling, cutting and forming. 0000001677 00000 n overprinted matter with the over printing instructions should check as in-process check, as per quality system, collected and inspected piece of blister foil should signed by IPQA, counter sign by Packing section in-charge and finallythis signed foil is a specimen and should affixed in BMR. Is there any differeneation in name for blister packs that have the product that is partly hanging out, as seen in Kitchen Devil knife and screwdriver. HW6UkD o'v:>pHHbY,4 RfJ9^`~$ Y~vy%X(.zz~/^AHS_H?O6ob&fJX,e But these criteria will only be met if the blister seal remains intact throughout the products shelf life. We offer a range of small scale, high quality blister packaging machines and medical device packaging solutions capable of handling all thermoform and cold-form materials. They are used on steel, brass, aluminum alloys and hard plastics. mechanical damage. Check out this diagram that showcases the variety of knurling tools for different applications. Right-hand diagonal knurl wheels are used to produce left-hand diagonal patterns. + C.F. Blister packs are created by means of a form-fill-seal process at the pharmaceutical company or designated contract packer. 0000023404 00000 n Blister packaging is made using several types of rugged polymers, including: Polyethylene terephthalate (PET) Polyvinyl chloride (PVC) Polyvinylidene chloride (PVDC) Check out this video below by YouTuber and machinist Joe Pieczynski. In other parts of the world, blister packs are the main packaging type since pharmacy dispensing and re-packaging are not common. A compact, lab scale medical device packaging machine that has been designed specifically for the medical device market. The machine has a range of options that can be selected to tailor and format the machine to meet individual commercial, manufacturing and technological requirements. Cobalt is harder than high speed steel and provides better wear resistance. Inaccurate knurl patterns may look great but it has the highest chances of rupturing under pressure, either while sealing or after finishing. HU}PewG!s 0000037880 00000 n A loss to the people adding their hours and a loss to the manufacturer of the medicine. This approach is most ideal for medium to large machining projects that require shoulderless diameter* knurling. The plastic shell is vacuum-formed around a mold so it can contain the item snugly. Your email address will not be published. Concerning pharma packaging, the material being used is as important a factor as the compounds being used in the production of the pill or capsule. This style of blister package is especially popular with custom packages with a shape that strongly indentifies with the brand of the product. and refers to the type of shape that the knurl is creating. But as they say, a stitch in time and prevention is better There are certain practices and steps taken pre-packaging that will ensure the sealing success you need for all your blistering sessions. Female diamond knurl wheels are used to create a male diamond knurl pattern. This is a multi-head knurling tool that features 6 separate wheels. Both have their limits and weaknesses. Another caveat is that micro channeling is not evident. The pattern that you choose, whether on a platen or rotary sealing tool, shall be decided knowing the pressure your machine will be putting on the material. The top card is die cut to fit the blister where the product sits. Depending on printing options, an all-paper blister package can be a more easily recycable option than a traditional plastic and paper blister package. Blister packs are useful for protecting products against external factors, such as humidity and contamination for extended periods of time. The first medicines that got blistered packed were Melabon and oral contraceptive.Thomas Lunsford takes the credit of blister packaging afterwards it evolved, now many different forms are available that can provide versatile options for various types of products. Here are a number of tips that must be considered as a standard procedure during packaging of pills and capsules with blistering machines. This packaging is generally designed for the product to stand upright on store shelves or be hung using a standard die-cut hang hole. Here are some to add to your before knurling checklist. Please enter valid partnumber and quantity. Cutting knurls are ideal for medium to larger sized workpiece diameters. Soft-temper foils are great when the packaging contains solid and sturdy products like hard lozenges, coated tablets or chewing gum. For different blister packaging, the blister, cavity, and box are different, as well as the shape, it will be different based on different products to be packed. This is because the material goes through a lot of physical strain passing through heat, pressure or alterations to chemical formations. 0000025545 00000 n 0000022333 00000 n of Knurl Diametral pitch knurls are designed to permit accurate tracking on standard fractional sized blanks. In-Process Checks During Blister Packaging. It is measured along the wheel from one tooth point to the next. The consumer can visually examine the product through the transparent plastic. The difference between a strip pack and blister pack is that a strip pack does not have thermo-formed or cold formed cavities; the strip pack is formed around the tablet at a time when it is dropped to the sealing area between sealing moulds. Unlike PVC and other common pharmaceutical barrier resins, cyclic olefin resins do not contain chlorine or other halogens in their molecular structure, being composed solely of carbon and hydrogen. Maintaining a good knurl pattern is as important as the recipe of the medicine it holds. Depending on the way in which these variations are selected and applied, hundreds of unique approaches to knurling are possible. When sealed in one of these latter three methods, they can be frustrating and even dangerous to open for consumers, but are very tamper resistant as a result. is essentially the same process just not as severe. Blistering sessions can be improved with many little tricks but the time you lose while getting to know your machine is expensive. In the industry these blisters are called cold form foil (CFF) blisters. From four decades of advising pharmaceutical operations on preventing and testing for leaky blister seals, we have amassed a great deal of knowledge around blister pack integrity and how to avoid seal issues. However, consideration also needs to be given to compatibility of base and lidding materials to guarantee seal integrity. #PVC or polyvinyl chloride is the most common blister packaging material. Or, instead of using two separate cards, the hinged card can have a die cut hole in the front panel for the blister to create a trapped blister package. 0000041846 00000 n This allows for a complete view of the product while providing plenty of eye-catching marketing real estate on the paperboard card. The mold is cooled such that the plastic becomes rigid again and maintains its shape when removed from the mold. Knurl forming is essentially the same process just not as severe. The PE (polyethylene) forms a soft intermediate layer between the rigid PVC and PVDC layers. Removing waste material from the sealing rollers, constantly polishing the blister patterns and knowing when to call for part change can bring efficiency all around. Single-Seal Blister Card Available in a variety of seal types, a single-seal is coated and heat-sealed to a thermoformed blister part. [6][7] Physical Properties. Thermoforming Blister pack is a term for several types of pre-formed plastic packaging used for small consumer goods, foods, and for pharmaceuticals. The most common lidding foil with push-through features is 20 hard tamper aluminum, which can be supplied pinhole-free from the producers. 0000003848 00000 n However, the is a lesser perceived value from consumers on products with skin packaging, so a low price point for your product is important. . hbbd``b`A All the while, this textured pattern remains consistent in size to form a uniform knurled surface. There are multiple types of knurls with different patterns and shapes. All rights reserved. In some parts of the world the pharmaceutical blister pack is known as a push-through pack (PTP), an accurate description of two key properties (i) the lidding foil is brittle, making it possible to press the product out while breaking the lidding foil and (ii) a semi-rigid formed cavity being sufficiently collapsible to be able to dispense the tablet or capsule by means of pressing it out with the thumb. See information below. Aspects of packaging 1.1 General considerations Packaging may be dened as the collection of different components (e.g. Blister packaging has many construction options to create the perfect package for your product. The most errors that occur with the forming and sealing procedures occur due to wrong temperatures and pressure. We recommend that packs should be designed with a minimum of 5mm between each cavity as well as to the outer edge of the card. The. This involves a thin film (usually Dupont Surlyn) that is placed over the product and the paperboard card. The flange of the blister is sealed and trapped between the front and back cards that are sealed together. All-Paper Blister Made completely of paper - including the blister - more of the package surface is available for full-color printing. PVDC is the most common coat-ing in blister packaging because it can re-duce the gas and moisture permeabilityof PVC blister packages by a factor of5-10. The Different Types of Tablet Packing Machines A wide variety of tablet packaging machines are available from different manufacturers. , . The parts that come in contact with the drug and packaging during blistering sessions are critical. Welcome to MSC, this site is screen reader friendly. The knurl pattern plays an important role in enforcing seal strength. This popularity is due in part to it not suffering the environmental liability that PVC suffers in discharging hydrochloric acid during incineration. Aclamshellis a container withtwo halves that are hinged to open and close, just like a clam. endstream endobj startxref Types of Packaging - The Blister Pack "Blister pack" is a general term that describes packaging that uses a process known as thermoforming. Wrap rage is sometimes the result. While this is technically a full face seal blister, the thermoformed plastic does not extend to the hang tab area. This wheel is made out of high speed steel for wear resistance and is used to form metal, not cut. . %PDF-1.4 % zo-8_td0%!XLCF8Q($N95eSRfLf* t* SwNg]Yfu~~`U69(/gD+O#dzF6u^uy7[&K,d~+F^/P8! h-p1O?^COAb-}EQimShWb`Kd[J. Maintaining sealing plates. Choice of knurl pattern on the sealing tool plays a role in seal integrity too. This will need to be done more frequently on blister packaging machines running printed materials as build-up of ink can distort the knurl pattern by preventing the upper and lower sealing tools from interlocking properly, leading to areas of weakness across the seal and micro-channeling. 9g}F8C$b#>#>=!HIp.U6eL|MR5X3aBh^9y$Z ]FeXDNHRs2rl"CK![p,uQP{Df5! Mock clamshells are often half the price of regular clamshells. All Rights Reserved. Why blister packaging is preferred by pharma companies. Blister Packaging vs Bottles for Pharmaceutical Products, Procedures and Machinery Used in Pharmaceutical Sampling, Accurate format parts for your machines are necessary. For example, the handle of a hand tool can be knurled so that the hand does not slip off and a firm grip is maintained. The Right Type of Blister Packaging for Your Product. Interested in learning more about the tools you will need to be successful in knurling applications? Many blister packaging machines use heat and pressure via a die to form the cavity or pocket from a roll or sheet of plastic. It also makes sense to vary the knurl depending on the web width. PVDC grades are available in 2 types of polymer: (I) the historic grades offering medium to high barrier properties and (II) a super barrier coating grade offering the highest barrier. Q2. There are a couple reasons for knurling. Beveled edge wheels are best for forming operations. Robots handle sensitive parenteralia bags in pharma facility, PCR Content Popularity Gains on the Horizon. Different projects will require completely different knurling criteria. Blister packaging helps shoppers see product, further aiding in their purchase decision. I hope this gives you a basic idea of the different types of blister packaging as well as some popular blister alternatives. Required fields are marked *. Bump Knurlers are used for holding knurl wheels to form a pattern or gripping surface on small- to medium-sized workpieces. Opaque blisters also protect light-sensitive products against UV rays. The term blister refers to the pocket of thermoformed plastic that covers the product. 0000014180 00000 n Learn more about our packaging solutions that are flexible, adaptable and capable of handling complex pack designs at minimal cost. Buying custom packaging is finally explained and has never been easier to do. There are two types of knurling, cutting and forming. The seal is only on the flange while the rest of the card stays uncovered. 0000021700 00000 n The primary component of a blister pack is a cavity, or pocket, frequently made from inexpensive and easily-thermoformed polyvinyl chloride (PVC). Clear, protective, and durable thermoformed plastic packaging enables the customer to fully view the product while maintaining the security of the product. Medical blister trays differ from pharmaceutical blister packs in that these are not push-through packs. PVDC coated blister films are the most common and prevailing barrier films used for pharmaceutical blister packs. In order to overcome the lack of barrier properties of PVC film, it can be coated with PVDC or laminated to PCTFE or COC to increase the protective properties. It completely blocks the passage of light and entry of unwanted odours. Language links are at the top of the page across from the title. Forming a deeper, wider impression the first time around helps to assure that the teeth will track into the initial grooves for all subsequent revolutions. 0000011077 00000 n The knurled blank should be close to the collet and large enough in diameter to prevent deflection. There are several different types of blister packaging Face Seal, Trap, Mock, Slide and Interactive. Convex knurls on the other hand have a sharp leading edge to provide a very smooth and precise finish. 0000038184 00000 n This entails TPI (the number of teeth per inch), the circular pitch (the distance between tooth to tooth), and the diametral pitch (the number of teeth per inch of workpiece diameter). 1 What is importance of knurling in blister packing. Diamond Pattern Tip: Traversing is not recommended when using diamond knurls. Perhaps you have decided you want to switch up your knurling pattern. Blister packs are used to package products such as toys, hardware, medication, etc. Both of which are knurling processes achieved by pressing the knurl pattern into a round workpiece. Take Healthcare Packaging's supply chain quiz to prove your knowledge! The most basic material for the forming web is polyvinyl chloride (PVC). They provide a smooth and precise finish. Blister Pack Tooling - Thermoform, Cold Form, Upper Seal Tools, Cutting Dies Pharmaceutical Tooling Our engineers, shop leaders, and toolmakers have over 350 years combined experience on thermoform and cold form tooling for all major European manufactured form-fill-seal machines. Tooling costs for the heat seal can be expensive for these face seal blister packs, but a trapped blister (see below) doesnt require heat seal. A mock clamshell is a one piece blister where the blister card is sealed to the back of the blister. All thermo-forming machinery operators must know that the material used in blistering can have an effect on the drug. Intermittent platen sealing systems require higher pressure and longer sealing times, and tend to seal at a lower temperature because of these longer dwell times. A lot of dirt, grime and residue from materials can sediment along the linings of the sealing tools. ), choosing a blank diameter for circular pitch knurls is a bit more difficult and usually involves experimentation. WVTR values of commercial cyclic olefin-based pharmaceutical blister films typically range from 0.20 to 0.35 g/m2/day at 38C/90% RH. Many of those specifications will be outlined via the project requirements, however others will be up to you to figure out. 'Pharmaceutical Packaging: the silent bodyguard'. They are used on steel, brass, aluminum alloys and hard plastics. Thermoforming involves heating a sheet of plastic to a temperature where it can be easily formed and molded into any desired shape. Wrong pressure might either harm the main PVC film or cause the sealing foil to detach even after the heat sealing is done. For blister packaging, each tablet or capsule is individually sealed, so any form of tampering is immediately visible. Blister packs are commonly used as unit-dose packaging for pharmaceutical tablets, capsules or lozenges. Especially with blister packaging, the idea is to make the packaging session of each batch smooth. Other types of blister packs consist of carded packaging where goods such as toys, hardware, and electrical items are contained between a specially made paperboard card and clear pre-formed plastic such as PVC. The card is colored and designed depending on the item inside, and the PVC is affixed to the card using heat and pressure to activate an adhesive (heat seal coating) on the blister card. Some popular knurl patterns are straight, diagonal, and diamond. It is very strong, robust packaging and excellent for heavy products. There is a wide range of colors and finishes that blister packaging can be constructed to feature. These methods can be based on melting and joining of sealant layers using heat sealing or on the application of a cold-seal adhesive coating to the inner surface of the packaging film.2Heat sealing is the most common method, which has been used for decades to shape and close the plastic packaging materials in the food industry. Our products enable customers to create high quality blister packs, to accurately detect leaks and weak seals in packaging, and to recover high value products from blister packs. Blister packs can provide barrier protection for shelf life requirements, and a degree of tamper resistance. Use smaller knurls on a narrow web, since the air can escape more easily. >#i\DbQ6sz6W&2(~yu?c4TE^\oh5a$bN)^d21KP pd1sE? Maximising the seal area. Cyclic olefin copolymers (COC) or polymers (COP) can provide moisture barrier to blister packs, typically in multilayered combinations with polypropylene (PP), polyethylene (PE), or glycol-modified polyethylene terephthalate (PETg). It is crucial to choose wisely between hard-temper aluminum and soft-temper aluminum. 0000040418 00000 n The product is surrounded by a clear plastic film and sits in a die-cut (cutout) area in the paperboard card. 0000003549 00000 n The tool holder measures 5/16 wide x 3/4 tall. 1 Like AsifHussain(Md.Asif Hussain) October 16, 2018, 5:30pm 2 Knurling in the blister help in proper sealing of the blister and proper knurling prevent blister from leak test failure.Proper Knurling shows good blister quality. If the workpiece material is on the harder side, cutting is your best bet. EZ Blister is a compact, customizable machine ideal for blister packaging of tablets, capsules, ampoules, sachets, pouches and other products. The sealing system will have an important bearing on the quality of the seal. Face Seal The most common type of blister package, a front face blister package includes a flanged thermoformed blister and a paperboard backing card. It consists of one sheet folded over onto itself and sometimes fused at the edges. 0000038579 00000 n In addition, it offers a higher perceived value because it looks nicer than the standard face seal blister, butof course is more expensive. The warm plastic will then arrive in a forming station where a large pressure (4 to 8 bar) will form the blister cavity into a negative mold. |Ozf](JbQI.{. fBVB al1L2'`7"*yU By far the most common and inexpensive destructive blister leakage test is the vacuum test using methylene blue. In order to obtain the ideal results in safe and efficient pharma packaging, it is necessary to create a process that equalizes every packaging session. One disadvantage of platen sealing is that it can cause air to be trapped in the blister pockets. The Sepha EZ Blister MAP offers Modified Atmospheric Packaging options (MAP). Scissor & Straddle Knurlers are designed to clamp/hold a pair of opposing knurls. aH{pZ'sGr5dZq(zH5'9JL,X:0v13N`4} ( 6@ P?*o cq"G[J?w?PbFCS HUZW"*Z}lg>/u*R#:c(-W: y&T=]Z_E8.(USWf-L%`9wKE2\yh&M.|c^L9w?U:FlCP)vAWG'Ecys||k](P'mu$t775 Qs9vIt7{7N6S4xls O_LUq8AhL The primary component of a blister pack is a cavity or pocket made from a formable web, usually a thermoformed plastic. This occurs when either too much or uneven sealing force is applied and the knurl punctures the lidding foil. 0000006698 00000 n Advertising space [ edit] There is a wide range of colors and finishes that blister packaging can be constructed to feature. This type is similar to the previously mentioned blisters, but instead of heat sealing the blister to the card, it is trapped between two cards. Stretch Paks can stand on their own on store shelves or be hung using a die-cut hang hole. Plate pressing type: Used for "dot sealing," more pressure is required from the machine to fully seal the blister to the backing since the blister packaging is flatter. The film producer applies the coating in several steps, drying-off the water between each coating station. Heat and sometimes vacuum is applied in order to adhere the film tightly onto the product and card. Pro Pac distributes packaging materials and packaging machinery across the country. They can be securely heat sealed, making them difficult to open by hand to deter tampering. Knurling Wheel Sets are also available. Female diamond wheels are only recommended if a two-wheel knurling tool is unavailable. Grizzly Industrial H7571 Floating Knurling Tool. The first reason is aesthetic as knurling is a decorative finishing process that develops a texture on the given workpiece. In addition, the design of the upper sealing tool should activate the adhesive layer in the lidding material evenly by applying heat uniformly. Quality Audit: Introduction, Types and Procedure, Aurobindo Pharma Ltd-Job Openings for M.Sc Freshers, SOP on Receipt of Raw Materials and Packaging Materials, Product Recall: Introduction, Classification and Recall Strategy, In-Process control & Inspection for the Small Volume Injectable (SVPs).